Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma

Despite the development of new targeted and immune therapies, the prognosis of metastatic melanoma remains bleak. Therefore, it is critical to better understand the mechanisms controlling advanced melanoma to develop more effective treatment regimens. Hedgehog/GLI (HH/GLI) signaling inhibitors targe...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Pietrobono, Silvia, Gaudio, Eugenio, Gagliardi, Sinforosa, Zitani, Mariapaola, Carrassa, Laura, Migliorini, Francesca, Petricci, Elena, Manetti, Fabrizio, Makukhin, Nikolai, Bond, Adam G., Paradise, Brooke D., Ciulli, Alessio, Fernandez-Zapico, Martin E., Bertoni, Francesco, Stecca, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8175236/
https://ncbi.nlm.nih.gov/pubmed/33958721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-021-01783-9
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