Novel Acylguanidine Derivatives Targeting Smoothened Induce Antiproliferative and Pro-Apoptotic Effects in Chronic Myeloid Leukemia Cells

The most relevant therapeutic approaches to treat CML rely on the administration of tyrosine kinase inhibitors (TKIs) like Imatinib, which are able to counteract the activity of Bcr-Abl protein increasing patient’s life expectancy and survival. Unfortunately, there are some issues TKIs are not able...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Chiarenza, Alessandra, Manetti, Fabrizio, Petricci, Elena, Ruat, Martial, Naldini, Antonella, Taddei, Maurizio, Carraro, Fabio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4774938/
https://ncbi.nlm.nih.gov/pubmed/26934052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149919
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