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Novel Acylguanidine Derivatives Targeting Smoothened Induce Antiproliferative and Pro-Apoptotic Effects in Chronic Myeloid Leukemia Cells

The most relevant therapeutic approaches to treat CML rely on the administration of tyrosine kinase inhibitors (TKIs) like Imatinib, which are able to counteract the activity of Bcr-Abl protein increasing patient’s life expectancy and survival. Unfortunately, there are some issues TKIs are not able...

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Publicat a:PLoS One
Autors principals: Chiarenza, Alessandra, Manetti, Fabrizio, Petricci, Elena, Ruat, Martial, Naldini, Antonella, Taddei, Maurizio, Carraro, Fabio
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4774938/
https://ncbi.nlm.nih.gov/pubmed/26934052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149919
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