Novel Acylguanidine Derivatives Targeting Smoothened Induce Antiproliferative and Pro-Apoptotic Effects in Chronic Myeloid Leukemia Cells

The most relevant therapeutic approaches to treat CML rely on the administration of tyrosine kinase inhibitors (TKIs) like Imatinib, which are able to counteract the activity of Bcr-Abl protein increasing patient’s life expectancy and survival. Unfortunately, there are some issues TKIs are not able...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Chiarenza, Alessandra, Manetti, Fabrizio, Petricci, Elena, Ruat, Martial, Naldini, Antonella, Taddei, Maurizio, Carraro, Fabio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4774938/
https://ncbi.nlm.nih.gov/pubmed/26934052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149919
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