MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor

The Smoothened (Smo) receptor, a member of class F G protein–coupled receptors, is the main transducer of the Hedgehog (Hh) signaling pathway implicated in a wide range of developmental and adult processes. Smo is the target of anticancer drugs that bind to a long and narrow cavity in the 7-transmem...

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Detaylı Bibliyografya
Yayımlandı:FASEB J
Asıl Yazarlar: Hoch, Lucile, Faure, Helene, Roudaut, Hermine, Schoenfelder, Angele, Mann, Andre, Girard, Nicolas, Bihannic, Laure, Ayrault, Olivier, Petricci, Elena, Taddei, Maurizio, Rognan, Didier, Ruat, Martial
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Federation of American Societies for Experimental Biology 2015
Konular:
Research Communication
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415011/
https://ncbi.nlm.nih.gov/pubmed/25636740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-267849
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