Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway

Hedgehog (Hh) is a critical regulator of adipogenesis. Extracellular vesicles are natural Hh carriers, as illustrated by activated/apoptotic lymphocytes specifically shedding microparticles (MP) bearing the morphogen (MP(Hh+)). We show that MP(Hh+) inhibit adipocyte differentiation and orientate mes...

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Udgivet i:Sci Rep
Main Authors: Fleury, Audrey, Hoch, Lucile, Martinez, M. Carmen, Faure, Hélène, Taddei, Maurizio, Petricci, Elena, Manetti, Fabrizio, Girard, Nicolas, Mann, André, Jacques, Caroline, Larghero, Jérôme, Ruat, Martial, Andriantsitohaina, Ramaroson, Le Lay, Soazig
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4806302/
https://ncbi.nlm.nih.gov/pubmed/27010359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23479
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