Combination therapy in the Col1a2(G610C) mouse model of Osteogenesis Imperfecta reveals an additive effect of enhancing LRP5 signaling and inhibiting TGFβ signaling on trabecular bone but not on cortical bone

Enhancing LRP5 signaling and inhibiting TGFβ signaling have each been reported to increase bone mass and improve bone strength in wild-type mice. Monotherapy targeting LRP5 signaling, or TGFβ signaling, also improved bone properties in mouse models of Osteogenesis Imperfecta (OI). We investigated wh...

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Dettagli Bibliografici
Pubblicato in:Bone
Autori principali: Kaupp, Shannon, Horan, Dan J., Lim, Kyung-Eun, Feldman, Henry A., Robling, Alexander G., Warman, Matthew L., Jacobsen, Christina M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7232829/
https://ncbi.nlm.nih.gov/pubmed/31648079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2019.115084
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