Targeting the LRP5 pathway improves bone properties in a mouse model of Osteogenesis Imperfecta

The cell surface receptor low-density lipoprotein receptor-related protein 5 (LRP5) is a key regulator of bone mass and bone strength. Heterozygous missense mutations in LRP5 cause autosomal dominant high bone mass (HBM) in humans by reducing binding to LRP5 by endogenous inhibitors, such as scleros...

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Detaylı Bibliyografya
Asıl Yazarlar: Jacobsen, Christina M., Barber, Lauren A., Ayturk, Ugur M., Roberts, Heather J., Deal, Lauren E., Schwartz, Marissa A., Weis, MaryAnn, Eyre, David, Zurakowski, David, Robling, Alexander G., Warman, Matthew L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4130796/
https://ncbi.nlm.nih.gov/pubmed/24677211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2198
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