Targeting the LRP5 pathway improves bone properties in a mouse model of Osteogenesis Imperfecta

The cell surface receptor low-density lipoprotein receptor-related protein 5 (LRP5) is a key regulator of bone mass and bone strength. Heterozygous missense mutations in LRP5 cause autosomal dominant high bone mass (HBM) in humans by reducing binding to LRP5 by endogenous inhibitors, such as scleros...

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Bibliografiska uppgifter
Huvudupphovsmän: Jacobsen, Christina M., Barber, Lauren A., Ayturk, Ugur M., Roberts, Heather J., Deal, Lauren E., Schwartz, Marissa A., Weis, MaryAnn, Eyre, David, Zurakowski, David, Robling, Alexander G., Warman, Matthew L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4130796/
https://ncbi.nlm.nih.gov/pubmed/24677211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2198
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