Combination therapy in the Col1a2(G610C) mouse model of Osteogenesis Imperfecta reveals an additive effect of enhancing LRP5 signaling and inhibiting TGFβ signaling on trabecular bone but not on cortical bone

Enhancing LRP5 signaling and inhibiting TGFβ signaling have each been reported to increase bone mass and improve bone strength in wild-type mice. Monotherapy targeting LRP5 signaling, or TGFβ signaling, also improved bone properties in mouse models of Osteogenesis Imperfecta (OI). We investigated wh...

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Detalhes bibliográficos
Publicado no:Bone
Main Authors: Kaupp, Shannon, Horan, Dan J., Lim, Kyung-Eun, Feldman, Henry A., Robling, Alexander G., Warman, Matthew L., Jacobsen, Christina M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7232829/
https://ncbi.nlm.nih.gov/pubmed/31648079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2019.115084
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