PAICS, a De Novo Purine Biosynthetic Enzyme, Is Overexpressed in Pancreatic Cancer and Is Involved in Its Progression

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with an extremely poor prognosis. There is an urgent need to identify new therapeutic targets and also understand the mechanism of PDAC progression that leads to aggressiveness of the disease. To find therapeutic targets, we analyzed da...

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Veröffentlicht in:Transl Oncol
Hauptverfasser: Agarwal, Sumit, Chakravarthi, Balabhadrapatruni V.S.K., Kim, Hyung-Gyoon, Gupta, Nirzari, Hale, Kevin, Balasubramanya, Sai Akshaya Hodigere, Oliver, Patsy G., Thomas, Dafydd G., Eltoum, Isam-Eldin A., Buchsbaum, Donald J., Manne, Upender, Varambally, Sooryanarayana
Format: Artigo
Sprache:Inglês
Veröffentlicht: Neoplasia Press 2020
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Original article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229293/
https://ncbi.nlm.nih.gov/pubmed/32422575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2020.100776
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