Targeting P4HA1 with a Small Molecule Inhibitor in a Colorectal Cancer PDX Model()

Deposition, remodeling, and signaling of the extracellular matrix facilitate tumor growth and metastasis. Here, we demonstrated that an enzyme, collagen prolyl 4-hydroxylase, alpha polypeptide I (P4HA1), which is involved in collagen synthesis and deposition, had elevated expression in colorectal ca...

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Detalhes bibliográficos
Publicado no:Transl Oncol
Main Authors: Agarwal, Sumit, Behring, Michael, Kim, Hyung-Gyoon, Bajpai, Prachi, Chakravarthi, Balabhadrapatruni V.S.K., Gupta, Nirzari, Elkholy, Amr, Al Diffalha, Sameer, Varambally, Sooryanarayana, Manne, Upender
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2020
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Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7082635/
https://ncbi.nlm.nih.gov/pubmed/32199274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2020.100754
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