Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer

Cancer cells exhibit altered metabolism including aerobic glycolysis that channels several glycolytic intermediates into de novo purine biosynthetic pathway. We discovered increased expression of phosphoribosyl amidotransferase (PPAT) and phosphoribosylaminoimidazole carboxylase, phosphoribosylamino...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Goswami, Moloy T., Chen, Guoan, Chakravarthi, Balabhadrapatruni V.S.K., Pathi, Satya S., Anand, Sharath K., Carskadon, Shannon L., Giordano, Thomas J., Chinnaiyan, Arul M., Thomas, Dafydd G., Palanisamy, Nallasivam, Beer, David G., Varambally, Sooryanarayana
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695129/
https://ncbi.nlm.nih.gov/pubmed/26140362
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