Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer

Cancer cells exhibit altered metabolism including aerobic glycolysis that channels several glycolytic intermediates into de novo purine biosynthetic pathway. We discovered increased expression of phosphoribosyl amidotransferase (PPAT) and phosphoribosylaminoimidazole carboxylase, phosphoribosylamino...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Goswami, Moloy T., Chen, Guoan, Chakravarthi, Balabhadrapatruni V.S.K., Pathi, Satya S., Anand, Sharath K., Carskadon, Shannon L., Giordano, Thomas J., Chinnaiyan, Arul M., Thomas, Dafydd G., Palanisamy, Nallasivam, Beer, David G., Varambally, Sooryanarayana
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695129/
https://ncbi.nlm.nih.gov/pubmed/26140362
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