Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

Protein arginine methyltransferases (PRMTs) regulate diverse biological processes and are increasingly being recognized for their potential as drug targets. Here we report the discovery of a potent, selective, and cell-active chemical probe for PRMT7. SGC3027 is a cell permeable prodrug, which in ce...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Szewczyk, Magdalena M., Ishikawa, Yoshinori, Organ, Shawna, Sakai, Nozomu, Li, Fengling, Halabelian, Levon, Ackloo, Suzanne, Couzens, Amber L., Eram, Mohammad, Dilworth, David, Fukushi, Hideto, Harding, Rachel, dela Seña, Carlo C., Sugo, Tsukasa, Hayashi, Kozo, McLeod, David, Zepeda, Carlos, Aman, Ahmed, Sánchez-Osuna, Maria, Bonneil, Eric, Takagi, Shinji, Al-Awar, Rima, Tyers, Mike, Richard, Stephane, Takizawa, Masayuki, Gingras, Anne-Claude, Arrowsmith, Cheryl H., Vedadi, Masoud, Brown, Peter J., Nara, Hiroshi, Barsyte-Lovejoy, Dalia
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224190/
https://ncbi.nlm.nih.gov/pubmed/32409666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16271-z
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