Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

Protein arginine methyltransferases (PRMTs) regulate diverse biological processes and are increasingly being recognized for their potential as drug targets. Here we report the discovery of a potent, selective, and cell-active chemical probe for PRMT7. SGC3027 is a cell permeable prodrug, which in ce...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Szewczyk, Magdalena M., Ishikawa, Yoshinori, Organ, Shawna, Sakai, Nozomu, Li, Fengling, Halabelian, Levon, Ackloo, Suzanne, Couzens, Amber L., Eram, Mohammad, Dilworth, David, Fukushi, Hideto, Harding, Rachel, dela Seña, Carlo C., Sugo, Tsukasa, Hayashi, Kozo, McLeod, David, Zepeda, Carlos, Aman, Ahmed, Sánchez-Osuna, Maria, Bonneil, Eric, Takagi, Shinji, Al-Awar, Rima, Tyers, Mike, Richard, Stephane, Takizawa, Masayuki, Gingras, Anne-Claude, Arrowsmith, Cheryl H., Vedadi, Masoud, Brown, Peter J., Nara, Hiroshi, Barsyte-Lovejoy, Dalia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224190/
https://ncbi.nlm.nih.gov/pubmed/32409666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16271-z
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