Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk

The tumor microenvironment (TME) plays a pivotal role in cancer progression, and, in ovarian cancer (OvCa), the primary TME is the omentum. Here, we show that the diabetes drug metformin alters mesothelial cells in the omental microenvironment. Metformin interrupts bidirectional signaling between tu...

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Udgivet i:Cell Rep
Main Authors: Hart, Peter C., Kenny, Hilary A., Grassl, Niklas, Watters, Karen M., Litchfield, Lacey M., Coscia, Fabian, Blaženović, Ivana, Ploetzky, Lisa, Fiehn, Oliver, Mann, Matthias, Lengyel, Ernst, Romero, Iris L.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7218928/
https://ncbi.nlm.nih.gov/pubmed/31851935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.11.079
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