Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk

The tumor microenvironment (TME) plays a pivotal role in cancer progression, and, in ovarian cancer (OvCa), the primary TME is the omentum. Here, we show that the diabetes drug metformin alters mesothelial cells in the omental microenvironment. Metformin interrupts bidirectional signaling between tu...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Hart, Peter C., Kenny, Hilary A., Grassl, Niklas, Watters, Karen M., Litchfield, Lacey M., Coscia, Fabian, Blaženović, Ivana, Ploetzky, Lisa, Fiehn, Oliver, Mann, Matthias, Lengyel, Ernst, Romero, Iris L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7218928/
https://ncbi.nlm.nih.gov/pubmed/31851935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.11.079
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