Old drug, new trick: Repurposing metformin for gynecologic cancers?

Por Febbraro, Terri, Lengyel, Ernst, Romero, Iris L.
Publicado no Gynecol Oncol (2014)

Adipose tissue and adipocytes supports tumorigenesis and metastasis()

Por Nieman, Kristin M., Romero, Iris L., Van Houten, Bennett, Lengyel, Ernst
Publicado em 2013

Molecular Pathways: Trafficking of Metabolic Resources in the Tumor Microenvironment

Por Romero, Iris L., Mukherjee, Abir, Kenny, Hilary A., Litchfield, Lacey M., Lengyel, Ernst
Publicado no Clin Cancer Res (2015)

Statin Therapy Is Associated with Improved Survival in Patients with Non-Serous-Papillary Epithelial Ovarian Cancer: A Retrospective Cohort Analysis

Por Habis, Mohammed, Wroblewski, Kristen, Bradaric, Michael, Ismail, Nadia, Yamada, S. Diane, Litchfield, Lacey, Lengyel, Ernst, Romero, Iris L.
Publicado em 2014

Foretinib (GSK1363089), an orally available multi-kinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces anoikis, and impairs ovarian cancer metastasis

Por Zillhardt, Marion, Park, Sun-Mi, Romero, Iris L., Sawada, Kenjiro, Montag, Anthony, Krausz, Thomas, Yamada, S. Diane, Peter, Marcus E., Lengyel, Ernst
Publicado em 2011

Relationship of Type II Diabetes and Metformin Use to Ovarian Cancer Progression, Survival, and Chemosensitivity

Por Romero, Iris L., McCormick, Anna, McEwen, Kelsey A., Park, SeoYoung, Karrison, Theodore, Yamada, S. Diane, Pannain, Silvana, Lengyel, Ernst
Publicado em 2012

Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer

Por Litchfield, Lacey M., Mukherjee, Abir, Eckert, Mark A., Johnson, Alyssa, Mills, Kathryn A., Pan, Shawn, Shridhar, Viji, Lengyel, Ernst, Romero, Iris L.
Publicado no Oncotarget (2015)

Metformin inhibits ovarian cancer growth and increases sensitivity to paclitaxel in mouse models

Por LENGYEL, Ernst, LITCHFIELD, Lacey M., MITRA, Anirban K., NIEMAN, Kristin M., MUKHERJEE, Abir, ZHANG, Yilin, JOHNSON, Alyssa, BRADARIC, Michael, LEE, WooSeok, ROMERO, Iris L.
Publicado no Am J Obstet Gynecol (2014)

Association of Metformin Use with Outcomes in Advanced Endometrial Cancer Treated with Chemotherapy

Por Ezewuiro, Obiageli, Grushko, Tatyana A., Kocherginsky, Masha, Habis, Mohammed, Hurteau, Jean A., Mills, Kathryn A., Hunn, Jessica, Olopade, Olufunmilayo I., Fleming, Gini F., Romero, Iris L.
Publicado no PLoS One (2016)

Effects of Oral Contraceptives or a Gonadotropin-releasing Hormone Agonist on Ovarian Carcinogenesis in Genetically Engineered Mice

Por Romero, Iris L., Gordon, Ilyssa O., Jagadeeswaran, Sujatha, Mui, Keeley L., Lee, Woo Seok, Dinulescu, Daniela M., Krausz, Thomas N., Kim, Helen H., Gilliam, Melissa L., Lengyel, Ernst
Publicado em 2009

The effects of 17β-estradiol and a selective estrogen receptor modulator, bazedoxifene, on ovarian carcinogenesis

Por Romero, Iris L., Lee, WooSeok, Mitra, Anirban K., Gordon, Ilyssa O., Zhao, Yan, Leonhardt, Payton, Penicka, Carla, Mui, Keeley L., Krausz, Thomas N., Greene, Geoffrey L., Lengyel, Ernst
Publicado em 2011

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

Por Nieman, Kristin M, Kenny, Hilary A, Penicka, Carla V, Ladanyi, Andras, Buell-Gutbrod, Rebecca, Zillhardt, Marion R, Romero, Iris L, Carey, Mark S, Mills, Gordon B, Hotamisligil, Gökhan S, Yamada, S Diane, Peter, Marcus E, Gwin, Katja, Lengyel, Ernst
Publicado em 2011

Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion

Por Kenny, Hilary A., Chiang, Chun-Yi, White, Erin A., Schryver, Elizabeth M., Habis, Mohammed, Romero, Iris L., Ladanyi, Andras, Penicka, Carla V., George, Joshy, Matlin, Karl, Montag, Anthony, Wroblewski, Kristen, Yamada, S. Diane, Mazar, Andrew P., Bowtell, David, Lengyel, Ernst
Publicado em 2014

Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer

Por Bowtell, David D., Böhm, Steffen, Ahmed, Ahmed A., Aspuria, Paul-Joseph, Bast, Robert C., Beral, Valerie, Berek, Jonathan S., Birrer, Michael J., Blagden, Sarah, Bookman, Michael A., Brenton, James, Chiappinelli, Katherine B., Martins, Filipe Correia, Coukos, George, Drapkin, Ronny, Edmondson, Richard, Fotopoulou, Christina, Gabra, Hani, Galon, Jérôme, Gourley, Charlie, Heong, Valerie, Huntsman, David G., Iwanicki, Marcin, Karlan, Beth Y., Kaye, Allyson, Lengyel, Ernst, Levine, Douglas A., Lu, Karen H., McNeish, Iain A., Menon, Usha, Narod, Steve A., Nelson, Brad H., Nephew, Kenneth P., Pharoah, Paul, Powell, Daniel J., Ramos, Pilar, Romero, Iris L., Scott, Clare L., Sood, Anil K., Stronach, Euan A., Balkwill, Frances R.
Publicado no Nat Rev Cancer (2015)