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Metformin inhibits ovarian cancer growth and increases sensitivity to paclitaxel in mouse models

OBJECTIVE: There is increasing pre-clinical evidence indicating that metformin, a medication commonly used for type 2 diabetes, may protect against cancer. Motivated by this emerging evidence we asked two questions: (a) can metformin prevent ovarian cancer growth by altering metabolism, and (b) will...

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Detalhes bibliográficos
Publicado no:Am J Obstet Gynecol
Main Authors: LENGYEL, Ernst, LITCHFIELD, Lacey M., MITRA, Anirban K., NIEMAN, Kristin M., MUKHERJEE, Abir, ZHANG, Yilin, JOHNSON, Alyssa, BRADARIC, Michael, LEE, WooSeok, ROMERO, Iris L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387077/
https://ncbi.nlm.nih.gov/pubmed/25446664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajog.2014.10.026
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