SUN-140 TMEPAI Inhibits SMAD 2/3 Mediated Muscle Wasting

Inhibition of myostatin and activin activity using ligand traps, such as soluble receptors, follistatin and propeptides, can markedly increase skeletal muscle mass in healthy mice and ameliorate wasting in models of cancer cachexia and muscular dystrophy. Though effective, clinical translation of th...

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Detalles Bibliográficos
Publicado en:J Endocr Soc
Main Authors: Kharoud, Swati, Walton, Kelly Louise, Hagg, Adam, Goodchild, Georgia, Chen, Justin, Thomson, Rachel, Qian, Hongwei, Gregorevic, Paul, Harrison, Craig Anthony
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
Assuntos:
Tumor Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7207501/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.1585
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