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Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis

Fibrosis occurs when there is an imbalance in extracellular matrix (ECM) deposition and degradation. Excessive ECM deposition results in scarring and thickening of the affected tissue, and interferes with tissue and organ homeostasis – mimicking an exaggerated “wound healing” response. Many transfor...

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Vydáno v:Front Pharmacol
Hlavní autoři: Walton, Kelly L., Johnson, Katharine E., Harrison, Craig A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509761/
https://ncbi.nlm.nih.gov/pubmed/28769795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00461
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