Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis

Fibrosis occurs when there is an imbalance in extracellular matrix (ECM) deposition and degradation. Excessive ECM deposition results in scarring and thickening of the affected tissue, and interferes with tissue and organ homeostasis – mimicking an exaggerated “wound healing” response. Many transfor...

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Bibliografiske detaljer
Udgivet i:Front Pharmacol
Main Authors: Walton, Kelly L., Johnson, Katharine E., Harrison, Craig A.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509761/
https://ncbi.nlm.nih.gov/pubmed/28769795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00461
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