TMEPAI/PMEPA1 Is a Positive Regulator of Skeletal Muscle Mass

Inhibition of myostatin- and activin-mediated SMAD2/3 signaling using ligand traps, such as soluble receptors, ligand-targeting propeptides and antibodies, or follistatin can increase skeletal muscle mass in healthy mice and ameliorate wasting in models of cancer cachexia and muscular dystrophy. How...

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Foilsithe in:Front Physiol
Main Authors: Hagg, Adam, Kharoud, Swati, Goodchild, Georgia, Goodman, Craig A., Chen, Justin L., Thomson, Rachel E., Qian, Hongwei, Gregorevic, Paul, Harrison, Craig A., Walton, Kelly L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2020
Ábhair:
Physiology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7672205/
https://ncbi.nlm.nih.gov/pubmed/33250771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.560225
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