Identification of RAG-like transposons in protostomes suggests their ancient bilaterian origin

BACKGROUND: V(D) J recombination is essential for adaptive immunity in jawed vertebrates and is initiated by the RAG1-RAG2 endonuclease. The RAG1 and RAG2 genes are thought to have evolved from a RAGL (RAG-like) transposon containing convergently-oriented RAG1-like (RAG1L) and RAG2-like (RAG2L) gene...

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Détails bibliographiques
Publié dans:Mob DNA
Auteurs principaux: Martin, Eliza C., Vicari, Célia, Tsakou-Ngouafo, Louis, Pontarotti, Pierre, Petrescu, Andrei J., Schatz, David G.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2020
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7204232/
https://ncbi.nlm.nih.gov/pubmed/32399063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13100-020-00214-y
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