Mapping and Quantitation of the Interaction between the Recombination Activating Gene Proteins RAG1 and RAG2

The RAG endonuclease consists of RAG1, which contains the active site for DNA cleavage, and RAG2, an accessory factor whose interaction with RAG1 is critical for catalytic function. How RAG2 activates RAG1 is not understood. Here, we used biolayer interferometry and pulldown assays to identify regio...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Zhang, Yu-Hang, Shetty, Keerthi, Surleac, Marius D., Petrescu, Andrei J., Schatz, David G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424321/
https://ncbi.nlm.nih.gov/pubmed/25745109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.638627
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