The architecture of the 12RSS in V(D)J recombination signal and synaptic complexes

V(D)J recombination is initiated by RAG1 and RAG2, which together with HMGB1 bind to a recombination signal sequence (12RSS or 23RSS) to form the signal complex (SC) and then capture a complementary partner RSS, yielding the paired complex (PC). Little is known regarding the structural changes that...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Ciubotaru, Mihai, Surleac, Marius D., Metskas, Lauren Ann, Koo, Peter, Rhoades, Elizabeth, Petrescu, Andrei J., Schatz, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333397/
https://ncbi.nlm.nih.gov/pubmed/25550426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1348
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