DNA bending in the synaptic complex in V(D)J recombination: turning an ancestral transpososome upside down

In all jawed vertebrates RAG (recombination activating gene) recombinase orchestrates V(D)J recombination in B and T lymphocyte precursors, assembling the V, D and J germline gene segments into continuous functional entities which encode the variable regions of their immune receptors. V(D)J recombin...

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Bibliographic Details
Published in:Discoveries (Craiova)
Main Authors: Ciubotaru, Mihai, Surleac, Marius, Musat, Mihaela G., Rusu, Andreea M., Ionita, Elena, Albu, Paul C. C.
Format: Artigo
Language:Inglês
Published: Applied Systems srl 2014
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941560/
https://ncbi.nlm.nih.gov/pubmed/32309545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15190/d.2014.5
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