Discovery of an Active RAG Transposon Illuminates the Origins of V(D)J Recombination

Co-option of RAG1 and RAG2 for antigen receptor gene assembly by V(D)J recombination was a crucial event in the evolution of jawed vertebrate adaptive immunity. RAG1/2 are proposed to have arisen from a transposable element, but definitive evidence for this is lacking. Here we report the discovery o...

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Publicado en:Cell
Autores principales: Huang, Shengfeng, Tao, Xin, Yuan, Shaochun, Zhang, Yuhang, Li, Peiyi, Beilinson, Helen A., Zhang, Ya, Yu, Wenjuan, Pontarotti, Pierre, Escriva, Hector, Le Petillon, Yann, Liu, Xiaolong, Chen, Shangwu, Schatz, David G., Xu, Anlong
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5017859/
https://ncbi.nlm.nih.gov/pubmed/27293192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.05.032
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