Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet

The discovery of ancestral RAG transposons in early deuterostomia reveals the origin of vertebrate V(D)J recombination. Here, we analyze the functional regulation of a RAG transposon, ProtoRAG, in lancelet. We find that a specific interaction between the cis-acting element within the TIR sequences o...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Liu, Song, Yuan, Shaochun, Gao, Xiaoman, Tao, Xin, Yu, Wenjuan, Li, Xu, Chen, Shangwu, Xu, Anlong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7481187/
https://ncbi.nlm.nih.gov/pubmed/32908127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18261-7
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