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An ancient evolutionary origin of the Rag1/2 gene locus

The diversity of antigen receptors in the adaptive immune system of jawed vertebrates is generated by a unique process of somatic gene rearrangement known as V(D)J recombination. The Rag1 and Rag2 proteins are the key mediators of this process. They are encoded by a compact gene cluster that has exc...

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Hlavní autoři: Fugmann, Sebastian D., Messier, Cynthia, Novack, Laura A., Cameron, R. Andrew, Rast, Jonathan P.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1450146/
https://ncbi.nlm.nih.gov/pubmed/16505374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509720103
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