Sirtuin 1 Inhibiting Thiocyanates (S1th)—A New Class of Isotype Selective Inhibitors of NAD(+) Dependent Lysine Deacetylases

Sirtuin 1 (Sirt1) is a NAD(+) dependent lysine deacetylase associated with the pathogenesis of various diseases including cancer. In many cancer types Sirt1 expression is increased and higher levels have been associated with metastasis and poor prognosis. However, it was also shown, that Sirt1 can h...

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Bibliographic Details
Published in:Front Oncol
Main Authors: Wössner, Nathalie, Alhalabi, Zayan, González, Jessica, Swyter, Sören, Gan, Jin, Schmidtkunz, Karin, Zhang, Lin, Vaquero, Alejandro, Ovaa, Huib, Einsle, Oliver, Sippl, Wolfgang, Jung, Manfred
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Oncology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7203344/
https://ncbi.nlm.nih.gov/pubmed/32426286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00657
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