Sirtuin 1 Inhibiting Thiocyanates (S1th)—A New Class of Isotype Selective Inhibitors of NAD(+) Dependent Lysine Deacetylases

Sirtuin 1 (Sirt1) is a NAD(+) dependent lysine deacetylase associated with the pathogenesis of various diseases including cancer. In many cancer types Sirt1 expression is increased and higher levels have been associated with metastasis and poor prognosis. However, it was also shown, that Sirt1 can h...

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Publicat a:Front Oncol
Autors principals: Wössner, Nathalie, Alhalabi, Zayan, González, Jessica, Swyter, Sören, Gan, Jin, Schmidtkunz, Karin, Zhang, Lin, Vaquero, Alejandro, Ovaa, Huib, Einsle, Oliver, Sippl, Wolfgang, Jung, Manfred
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Oncology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7203344/
https://ncbi.nlm.nih.gov/pubmed/32426286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00657
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