Identification of Bichalcones as Sirtuin Inhibitors by Virtual Screening and In Vitro Testing

Sirtuins are nicotinamide adenine dinucleotide (NAD(+))-dependent class III histone deacetylases, which have been linked to the pathogenesis of numerous diseases, including HIV, metabolic disorders, neurodegeneration and cancer. Docking of the virtual pan-African natural products library (p-ANAPL),...

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Publicado no:Molecules
Main Authors: Karaman, Berin, Alhalabi, Zayan, Swyter, Sören, Mihigo, Shetonde O., Andrae-Marobela, Kerstin, Jung, Manfred, Sippl, Wolfgang, Ntie-Kang, Fidele
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6017733/
https://ncbi.nlm.nih.gov/pubmed/29443909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23020416
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