Novel Histone Deacetylase Inhibitors and HIV-1 Latency-Reversing Agents Identified by Large-Scale Virtual Screening

Current antiretroviral therapies used for HIV management do not target latent viral reservoirs in humans. The experimental “shock-and-kill” therapeutic approach involves use of latency-reversal agents (LRAs) that reactivate HIV expression in reservoir-containing cells, followed by infected cell elim...

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Publicat a:Front Pharmacol
Autors principals: Divsalar, Donya Naz, Simoben, Conrad Veranso, Schonhofer, Cole, Richard, Khumoekae, Sippl, Wolfgang, Ntie-Kang, Fidele, Tietjen, Ian
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311767/
https://ncbi.nlm.nih.gov/pubmed/32625097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00905
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