Novel Histone Deacetylase Inhibitors and HIV-1 Latency-Reversing Agents Identified by Large-Scale Virtual Screening

Current antiretroviral therapies used for HIV management do not target latent viral reservoirs in humans. The experimental “shock-and-kill” therapeutic approach involves use of latency-reversal agents (LRAs) that reactivate HIV expression in reservoir-containing cells, followed by infected cell elim...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Divsalar, Donya Naz, Simoben, Conrad Veranso, Schonhofer, Cole, Richard, Khumoekae, Sippl, Wolfgang, Ntie-Kang, Fidele, Tietjen, Ian
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311767/
https://ncbi.nlm.nih.gov/pubmed/32625097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00905
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