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IL-21 is a broad negative regulator of IgE class switch recombination in mouse and human B cells
IgE antibodies may elicit potent allergic reactions, and their production is tightly controlled. The tendency to generate IgE has been thought to reflect the balance between type 1 and type 2 cytokines, with the latter promoting IgE. Here, we reevaluated this paradigm by a direct cellular analysis,...
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| Publicado no: | J Exp Med |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7201927/ https://ncbi.nlm.nih.gov/pubmed/32130409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190472 |
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