Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination

Preceding antibody constant regions are switch (S) regions varying in length and repeat density that are targets of activation-induced cytidine deaminase. We asked how participating S regions influence each other to orchestrate rearrangements at the IgH locus by engineering mice in which the weakest...

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Hlavní autoři: Misaghi, Shahram, Senger, Kate, Sai, Tao, Qu, Yan, Sun, Yonglian, Hamidzadeh, Kajal, Nguyen, Allen, Jin, Zhaoyu, Zhou, Meijuan, Yan, Donghong, Lin, Wei Yu, Lin, Zhonghua, Lorenzo, Maria N., Sebrell, Andrew, Ding, Jiabing, Xu, Min, Caplazi, Patrick, Austin, Cary D., Balazs, Mercedesz, Roose-Girma, Merone, DeForge, Laura, Warming, Søren, Lee, Wyne P., Dixit, Vishva M., Zarrin, Ali A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785764/
https://ncbi.nlm.nih.gov/pubmed/24019479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1221661110
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