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Sequential class switching is required for the generation of high affinity IgE antibodies
IgE antibodies with high affinity for their antigens can be stably cross-linked at low concentrations by trace amounts of antigen, whereas IgE antibodies with low affinity bind their antigens weakly. In this study, we find that there are two distinct pathways to generate high and low affinity IgE. H...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3280879/ https://ncbi.nlm.nih.gov/pubmed/22249450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111941 |
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