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Sequential class switching is required for the generation of high affinity IgE antibodies

IgE antibodies with high affinity for their antigens can be stably cross-linked at low concentrations by trace amounts of antigen, whereas IgE antibodies with low affinity bind their antigens weakly. In this study, we find that there are two distinct pathways to generate high and low affinity IgE. H...

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Bibliografiske detaljer
Main Authors: Xiong, Huizhong, Dolpady, Jayashree, Wabl, Matthias, Curotto de Lafaille, Maria A., Lafaille, Juan J.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280879/
https://ncbi.nlm.nih.gov/pubmed/22249450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111941
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