Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions

Ig heavy chain (IgH) class-switch recombination (CSR) replaces the IgH Cμ constant region exons with one of several sets of downstream IgH constant region exons (e.g., Cγ, Cε, or Cα), which affects switching from IgM to another IgH class (e.g., IgG, IgE, or IgA). Activation-induced cytidine deaminas...

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Autors principals: Zhang, Tingting, Franklin, Andrew, Boboila, Cristian, McQuay, Amy, Gallagher, Michael P., Manis, John P., Khamlichi, Ahmed Amine, Alt, Frederick W.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840363/
https://ncbi.nlm.nih.gov/pubmed/20133637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0915072107
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