Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination

Immunoglobulin heavy chain (IgH) class-switch recombination (CSR) replaces initially expressed Cμ (IgM) constant regions (C(H)) exons with downstream C(H) exons. Stimulation of B cells with anti-CD40 plus interleukin-4 induces CSR from Cμ to Cγ1 (IgG1) and Cε (IgE), the latter of which contributes t...

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Xehetasun bibliografikoak
Egile Nagusiak: Wesemann, Duane R., Magee, Jennifer M., Boboila, Cristian, Calado, Dinis Pedro, Gallagher, Michael P., Portuguese, Andrew J., Manis, John P., Zhou, Xiaolong, Recher, Mike, Rajewsky, Klaus, Notarangelo, Luigi D., Alt, Frederick W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3244039/
https://ncbi.nlm.nih.gov/pubmed/22143888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111155
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