Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination

Immunoglobulin heavy chain (IgH) class-switch recombination (CSR) replaces initially expressed Cμ (IgM) constant regions (C(H)) exons with downstream C(H) exons. Stimulation of B cells with anti-CD40 plus interleukin-4 induces CSR from Cμ to Cγ1 (IgG1) and Cε (IgE), the latter of which contributes t...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Wesemann, Duane R., Magee, Jennifer M., Boboila, Cristian, Calado, Dinis Pedro, Gallagher, Michael P., Portuguese, Andrew J., Manis, John P., Zhou, Xiaolong, Recher, Mike, Rajewsky, Klaus, Notarangelo, Luigi D., Alt, Frederick W.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3244039/
https://ncbi.nlm.nih.gov/pubmed/22143888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111155
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker