Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination

Immunoglobulin heavy chain (IgH) class-switch recombination (CSR) replaces initially expressed Cμ (IgM) constant regions (C(H)) exons with downstream C(H) exons. Stimulation of B cells with anti-CD40 plus interleukin-4 induces CSR from Cμ to Cγ1 (IgG1) and Cε (IgE), the latter of which contributes t...

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Autori principali: Wesemann, Duane R., Magee, Jennifer M., Boboila, Cristian, Calado, Dinis Pedro, Gallagher, Michael P., Portuguese, Andrew J., Manis, John P., Zhou, Xiaolong, Recher, Mike, Rajewsky, Klaus, Notarangelo, Luigi D., Alt, Frederick W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3244039/
https://ncbi.nlm.nih.gov/pubmed/22143888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111155
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