Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination

Immunoglobulin heavy chain (IgH) class-switch recombination (CSR) replaces initially expressed Cμ (IgM) constant regions (C(H)) exons with downstream C(H) exons. Stimulation of B cells with anti-CD40 plus interleukin-4 induces CSR from Cμ to Cγ1 (IgG1) and Cε (IgE), the latter of which contributes t...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Wesemann, Duane R., Magee, Jennifer M., Boboila, Cristian, Calado, Dinis Pedro, Gallagher, Michael P., Portuguese, Andrew J., Manis, John P., Zhou, Xiaolong, Recher, Mike, Rajewsky, Klaus, Notarangelo, Luigi D., Alt, Frederick W.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3244039/
https://ncbi.nlm.nih.gov/pubmed/22143888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111155
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados