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Switch Region Identity Plays an Important Role in Ig Class Switch Recombination

Ig class switch recombination (CSR) is regulated through long-range intrachromosomal interactions between germline transcript promoters and enhancers to initiate transcription and create chromatin accessible to activation-induced deaminase attack. CSR occurs between switch (S) regions that flank Cμ...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Bhattacharya, Palash, Wuerffel, Robert, Kenter, Amy L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979553/
https://ncbi.nlm.nih.gov/pubmed/20427773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000507
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