Trib1 regulates T cell differentiation during chronic infection by restraining the effector program

In chronic infections, the immune response fails to control virus, leading to persistent antigen stimulation and the progressive development of T cell exhaustion. T cell effector differentiation is poorly understood in the context of exhaustion, but targeting effector programs may provide new strate...

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Vydáno v:J Exp Med
Hlavní autoři: Rome, Kelly S., Stein, Sarah J., Kurachi, Makoto, Petrovic, Jelena, Schwartz, Gregory W., Mack, Ethan A., Uljon, Sacha, Wu, Winona W., DeHart, Anne G., McClory, Susan E., Xu, Lanwei, Gimotty, Phyllis A., Blacklow, Stephen C., Faryabi, Robert B., Wherry, E. John, Jordan, Martha S., Pear, Warren S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7201917/
https://ncbi.nlm.nih.gov/pubmed/32150623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190888
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