Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding

Tribbles homolog 2 (Trib2) is a pseudokinase that induces acute myelogenous leukemia (AML) in mice and is highly expressed in a subset of human AML. Trib2 has 3 distinct regions, a proline-rich N-terminus, a serine/threonine kinase homology domain, and a C-terminal constitutive photomorphogenesis 1...

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Auteurs principaux: Keeshan, Karen, Bailis, Will, Dedhia, Priya H., Vega, Maria E., Shestova, Olga, Xu, Lanwei, Toscano, Kristin, Uljon, Sacha N., Blacklow, Stephen C., Pear, Warren S.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2010
Sujets:
Myeloid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012589/
https://ncbi.nlm.nih.gov/pubmed/20805362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-10-247361
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