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Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding
Tribbles homolog 2 (Trib2) is a pseudokinase that induces acute myelogenous leukemia (AML) in mice and is highly expressed in a subset of human AML. Trib2 has 3 distinct regions, a proline-rich N-terminus, a serine/threonine kinase homology domain, and a C-terminal constitutive photomorphogenesis 1...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Society of Hematology
2010
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3012589/ https://ncbi.nlm.nih.gov/pubmed/20805362 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-10-247361 |
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