Differential ability of Tribbles family members to promote degradation of C/EBPα and induce acute myelogenous leukemia

Trib1, Trib2, and Trib3 are mammalian homologs of Tribbles, an evolutionarily conserved Drosophila protein family that mediates protein degradation. Tribbles proteins function as adapters to recruit E3 ubiquitin ligases and enhance ubiquitylation of the target protein to promote its degradation. Inc...

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Detalhes bibliográficos
Main Authors: Dedhia, Priya H., Keeshan, Karen, Uljon, Sacha, Xu, Lanwei, Vega, Maria E., Shestova, Olga, Zaks-Zilberman, Meirav, Romany, Candice, Blacklow, Stephen C., Pear, Warren S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938240/
https://ncbi.nlm.nih.gov/pubmed/20410507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-229450
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