Differential ability of Tribbles family members to promote degradation of C/EBPα and induce acute myelogenous leukemia

Trib1, Trib2, and Trib3 are mammalian homologs of Tribbles, an evolutionarily conserved Drosophila protein family that mediates protein degradation. Tribbles proteins function as adapters to recruit E3 ubiquitin ligases and enhance ubiquitylation of the target protein to promote its degradation. Inc...

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Bibliografische gegevens
Hoofdauteurs: Dedhia, Priya H., Keeshan, Karen, Uljon, Sacha, Xu, Lanwei, Vega, Maria E., Shestova, Olga, Zaks-Zilberman, Meirav, Romany, Candice, Blacklow, Stephen C., Pear, Warren S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2010
Onderwerpen:
Myeloid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938240/
https://ncbi.nlm.nih.gov/pubmed/20410507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-229450
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