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Tribbles-1 regulates hepatic lipogenesis through posttranscriptional regulation of C/EBPα

Variants near the gene TRIB1 are significantly associated with several plasma lipid traits, circulating liver enzymes, and the development of coronary artery disease in humans; however, it is not clear how its protein product tribbles-1 regulates lipid metabolism. Here, we evaluated mice harboring a...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Bauer, Robert C., Sasaki, Makoto, Cohen, Daniel M., Cui, Jian, Smith, Mikhaila A., Yenilmez, Batuhan O., Steger, David J., Rader, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607129/
https://ncbi.nlm.nih.gov/pubmed/26348894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI77095
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