Fixed Dosing of Liposomal Amphotericin B in Morbidly Obese Individuals

In this prospective study, we examined the pharmacokinetics of 1 and 2 mg/kg liposomal amphotericin B in 16 morbidly obese individuals (104–177 kg). Body size had no effect on clearance. We recommend a fixed dose in patients ≥100 kg (ie, 300 or 500 mg rather than the current dose of 3 and 5 mg/kg, r...

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Enregistré dans:
Détails bibliographiques
Publié dans:Clin Infect Dis
Auteurs principaux: Wasmann, Roeland E, Smit, Cornelis, van Dongen, Eric P H, Wiezer, René M J, Adler-Moore, Jill, de Beer, Yvo M, Burger, David M, Knibbe, Catherijne A J, Brüggemann, Roger J M
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
Sujets:
Brief Reports
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7201409/
https://ncbi.nlm.nih.gov/pubmed/31588493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciz885
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