Tobramycin Clearance Is Best Described by Renal Function Estimates in Obese and Non-obese Individuals: Results of a Prospective Rich Sampling Pharmacokinetic Study

PURPOSE: Tobramycin is an aminoglycoside antibiotic of which the 24 h exposure correlates with efficacy. Recently, we found that clearance of the aminoglycoside gentamicin correlates with total body weight (TBW). In this study, we investigate the full pharmacokinetic profile of tobramycin in obese a...

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Bibliographic Details
Published in:Pharm Res
Main Authors: Smit, Cornelis, Wasmann, Roeland E., Wiezer, Marinus J., van Dongen, Hendricus P. A., Mouton, Johan W., Brüggemann, Roger J. M., Knibbe, Catherijne A. J.
Format: Artigo
Language:Inglês
Published: Springer US 2019
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542779/
https://ncbi.nlm.nih.gov/pubmed/31147853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-019-2651-2
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