Tobramycin Clearance Is Best Described by Renal Function Estimates in Obese and Non-obese Individuals: Results of a Prospective Rich Sampling Pharmacokinetic Study

PURPOSE: Tobramycin is an aminoglycoside antibiotic of which the 24 h exposure correlates with efficacy. Recently, we found that clearance of the aminoglycoside gentamicin correlates with total body weight (TBW). In this study, we investigate the full pharmacokinetic profile of tobramycin in obese a...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Pharm Res
Main Authors: Smit, Cornelis, Wasmann, Roeland E., Wiezer, Marinus J., van Dongen, Hendricus P. A., Mouton, Johan W., Brüggemann, Roger J. M., Knibbe, Catherijne A. J.
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2019
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542779/
https://ncbi.nlm.nih.gov/pubmed/31147853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-019-2651-2
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